反应详情

A mixture of (E,E)-3,7,11-trimethyl-2,6,10-dodecatrienyl bromide (1.5 g, 5.26 mmol) and sodium azide (0.68 g, 10.5 mmol) in DMF (20 mL) was stirred at room temperature for 0.5 hours, then poured into cold water and extracted with ether. The ethereal extract was washed with brine, dried, filtered and evaporated to yield a residue. Purification of the residue by flash chromatography on a silica gel column, using hexane as the eluant, afforded the title compound as an oil (1.2 g, 4.85 mmol, 92%).

1. extractionextracted with ether
2. extractionThe ethereal extract
3. washwas washed with brine
4. customdried
5. filtrationfiltered
6. customevaporated
7. customto yield a residue
8. customPurification of the residue by flash chromatography on a silica gel column