HRID23796

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(CO[Si](C)(C)C(C)(C)C)c1ccc(CBr)cc1

HCID22590501

未命名化合物

结构：CC(C)(C)OC(=O)COc1cccc(CNS(=O)(=O)c2cccnc2)c1

HCID69730626

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)OC(=O)COc1cccc(CN(Cc2ccc(C(C)(C)CO[Si](C)(C)C(C)(C)C)cc2)S(=O)(=O)c2cccnc2)c1

HCID69729909

未命名化合物

PROCEDURE

实验过程

The title compound was prepared by alkylation of {3-[(pyridine-3-sulfonylamino)-methyl]-phenoxy}-acetic acid tert-butyl ester (122 mg, 0.322 mmol) with [2-(4-bromomethyl-phenyl)-2-methyl-propoxy]-tert-butyl-dimethyl-silane (121 mg, 0.339 mmol) following the procedure described for Example 1, Step A. The reaction time was 1 h. The crude product (238 mg) was used in the next step without purification. MS 655 (M+1).

WORKUP

后处理

customThe crude product (238 mg) was used in the next step without purification

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-a1b03d1712dd49f2bbd9af9fca405b29
来源数据集: uspto-grants-2005_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06852863B2
来源说明: uspto-grants-2005_02

反应 SMILES

[C:1]([O:5][C:6](=[O:26])[CH2:7][O:8][C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([CH2:15][NH:16][S:17]([C:20]2[CH:21]=[N:22][CH:23]=[CH:24][CH:25]=2)(=[O:19])=[O:18])[CH:10]=1)([CH3:4])([CH3:3])[CH3:2].Br[CH2:28][C:29]1[CH:34]=[CH:33][C:32]([C:35]([CH3:46])([CH3:45])[CH2:36][O:37][Si:38]([C:41]([CH3:44])([CH3:43])[CH3:42])([CH3:40])[CH3:39])=[CH:31][CH:30]=1>>[C:1]([O:5][C:6](=[O:26])[CH2:7][O:8][C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([CH2:15][N:16]([CH2:28][C:29]2[CH:30]=[CH:31][C:32]([C:35]([CH3:46])([CH3:45])[CH2:36][O:37][Si:38]([C:41]([CH3:44])([CH3:43])[CH3:42])([CH3:39])[CH3:40])=[CH:33][CH:34]=2)[S:17]([C:20]2[CH:21]=[N:22][CH:23]=[CH:24][CH:25]=2)(=[O:19])=[O:18])[CH:10]=1)([CH3:4])([CH3:2])[CH3:3]