[2-(4-Bromomethyl-phenyl)-2-methyl-propoxy]-tert-butyl-dimethyl-silane → (3-{[{4-[2-(tert-Butyl-dimethyl-silanyloxy)-1,1-dimethyl-ethyl]-benzyl}-(pyridine-3-sulfonyl)-amino]-methyl}-phenoxy)-acetic acid tert-butyl ester

Participants

Reaction Steps

The title compound was prepared by alkylation of {3-[(pyridine-3-sulfonylamino)-methyl]-phenoxy}-acetic acid tert-butyl ester (122 mg, 0.322 mmol) with [2-(4-bromomethyl-phenyl)-2-methyl-propoxy]-tert-butyl-dimethyl-silane (121 mg, 0.339 mmol) following the procedure described for Example 1, Step A. The reaction time was 1 h. The crude product (238 mg) was used in the next step without purification. MS 655 (M+1).

Provenance & Evidence