Dimethylamine → N-(4-dimethylamino-6-chloropyrimidin-5-yl)-cis-9-octadecenamide

HRID 2379634Notes

Reaction equation

HRID 2379634 reaction equation
[NH2:1][C:2]1[C:3]([N:9]([CH3:11])[CH3:10])=[N:4][CH:5]=[N:6][C:7]=1[Cl:8].NC1C(Cl)=NC=NC=1Cl.CNC.[C:24](Cl)(=[O:42])[CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31]/[CH:32]=[CH:33]\[CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH3:41]>>[CH3:10][N:9]([CH3:11])[C:3]1[C:2]([NH:1][C:24](=[O:42])[CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31]/[CH:32]=[CH:33]\[CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH3:41])=[C:7]([Cl:8])[N:6]=[CH:5][N:4]=1

Participants

5

Reactant 4

HCID 674DimethylamineHCID 794345-Amino-4,6-dichloropyrimidineHCID 7689556-Chloro-N4,N4-dimethylpyrimidine-4,5-diamineHCID 5364783Oleoyl chloride

Product 1

HCID 86748242N-(4-dimethylamino-6-chloropyrimidin-5-yl)-cis-9-octadecenamide

Procedure

5-Amino-4-(dimethyl)amino-6-chloropyrimidine (prepared by reacting commercially available 5-amino-4,6-dichloropyrimidine with excess dimethylamine) was coupled with oleoyl chloride according to the procedure described in Example 4 to give the title compound.

Sources & evidence

ORD record
ord-fed3dd7bb72a42e9a1256dcb784c4cc7
Source dataset
uspto-grants-1994_11
Patent number
US05362878

Reaction notes

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