Benzylamine → HCID 18757511, compound

HRID 2379654Notes

Reaction equation

HRID 2379654 reaction equation
C([O:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]([O:13][CH:14]([CH3:21])[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH3:20])=[O:12])=[CH:7][C:6]=1[F:22])(=O)C.C(N)C1C=CC=CC=1>C(O)C.CCOCC>[OH:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]([O:13][CH:14]([CH3:21])[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH3:20])=[O:12])=[CH:7][C:6]=1[F:22]

Participants

5

Reactant 2

HCID 7504BenzylamineHCID 18955762HCID 18955762, compound

Product 1

HCID 18757511HCID 18757511, compoundYield 63.1%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 3283Diethyl EtherSolvent

Procedure

The above compound (3) (1.1 g) was dissolved in 30 ml of ethanol, and 3 g of benzylamine was added dropwise. The mixture was stirred at room temperature for 24 hours, then diluted with 300 ml of ether, washed with dilute hydrochloric acid and water in this sequence, and dried over magnesium sulfate. After the solvent was evaporated, the solid was purified by silica gel column chromatograhy to afford 0.6 g of a final product (4).

Workup

  1. washwashed with dilute hydrochloric acid and water in this sequence
  2. dry with materialdried over magnesium sulfate
  3. customAfter the solvent was evaporated
  4. customthe solid was purified by silica gel column chromatograhy

Sources & evidence

ORD record
ord-5d1e906750724a99a009386a5232b666
Source dataset
uspto-grants-1994_11
Patent number
US05364560

Reaction notes

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