HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyl Chloride → Ethyl 2-(1-benzylpiperidin-4-yl)acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyl Chloride | HCID 7503 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Ethyl 2-(piperidin-4-yl)acetate | HCID 2760465 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Ethyl 2-(1-benzylpiperidin-4-yl)acetate | HCID 10400444 | — |
Reaction Steps
Ethyl 4-piperidylacetate was dissolved in 50 ml CH2Cl2 while chilling the mixture on an ice bath, 3.1 ml (22 mmol) triethylamine then benzyl chloride was added; the mixture was refluxed for 2 hours. After cooling the organic layer was extracted with water, brine and then dried over magnesium sulfate. After crystallization, 2.05 g of ethyl N-benzyl-4-piperidylacetate was obtained (Formula XI: Y'=CH2, alkyl=C2H5).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05364865 |
| Source dataset | uspto-grants-1994_11 |
| ORD ID | ord-87b5cd366eac4fb1a410afd0123cc0e8 |
| Source note | uspto-grants-1994_11 |