反应详情

Ethyl 4-piperidylacetate was dissolved in 50 ml CH2Cl2 while chilling the mixture on an ice bath, 3.1 ml (22 mmol) triethylamine then benzyl chloride was added; the mixture was refluxed for 2 hours. After cooling the organic layer was extracted with water, brine and then dried over magnesium sulfate. After crystallization, 2.05 g of ethyl N-benzyl-4-piperidylacetate was obtained (Formula XI: Y'=CH2, alkyl=C2H5).

1. temperaturewhile chilling the mixture on an ice bath
2. temperaturethe mixture was refluxed for 2 hours
3. temperatureAfter cooling the organic layer
4. extractionwas extracted with water, brine
5. dry with materialdried over magnesium sulfate
6. customAfter crystallization