Fenbuconazole → HCID 15790296, compound

HRID 2379733Notes

Reaction equation

HRID 2379733 reaction equation
[H-].[Al+3].[Li+].[H-].[H-].[H-].[Cl:7][C:8]1[CH:13]=[CH:12][C:11]([CH2:14][CH2:15][C:16]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)([CH2:19][N:20]2[CH:24]=[N:23][CH:22]=[N:21]2)[C:17]#[N:18])=[CH:10][CH:9]=1>O1CCCC1>[Cl:7][C:8]1[CH:13]=[CH:12][C:11]([CH2:14][CH2:15][C:16]([C:25]2[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=2)([CH2:19][N:20]2[CH:24]=[N:23][CH:22]=[N:21]2)[CH2:17][NH2:18])=[CH:10][CH:9]=1

Participants

4

Reactant 2

HCID 86138FenbuconazoleHCID 21226445Aluminium lithium hydride

Product 1

HCID 15790296HCID 15790296, compoundYield 89.5%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A slurry of 18 g (0.45 mole) of lithium aluminum hydride in 1000 mL of dry tetrahydrofuran was cooled to 5° C. while stirring under nitrogen. To the slurry was added alpha-(2-(4-chlorophenyl)ethyl)-alpha-phenyl-1H-1,2,4-triazole-1-propanenitrile in 2000 mL of dry., tetrahydrofuran over 3 hours. The reaction was kept at 5°-10° C. during the addition then allowed to warm to room temperature and stirred overnight. The reaction was cooled in an ice bath and quenched with the slow addition of sodium sulfate. The solvent was removed and the residue was extracted with ethyl acetate and washed with 1000 mL water and 1000 mL brine. After drying, and removal of the solvent, 137 g (89.5% yield) of a very viscous oil resulted.

Workup

  1. customof dry
  2. additionThe reaction was kept at 5°-10° C. during the addition
  3. stirringstirred overnight
  4. temperatureThe reaction was cooled in an ice bath
  5. customquenched with the slow addition of sodium sulfate
  6. customThe solvent was removed
  7. extractionthe residue was extracted with ethyl acetate
  8. washwashed with 1000 mL water and 1000 mL brine
  9. customAfter drying
  10. customremoval of the solvent, 137 g (89.5% yield) of a very viscous oil
  11. customresulted

Sources & evidence

ORD record
ord-56dffdbca1ca49edb5650192d421188e
Source dataset
uspto-grants-1994_11
Patent number
US05364870

Reaction notes

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