Potassium Carbonate → HCID 14210546, compound

HRID 2379757Notes

Reaction equation

HRID 2379757 reaction equation
[Na+].[N:2]1[CH:7]=[CH:6][C:5]([C:8]([O-:10])=[O:9])=[CH:4][C:3]=1[C:11]([O-:13])=[O:12].[Na+].[CH3:15][C:16]1[O:20][C:19](=[O:21])[O:18][C:17]=1[CH2:22]Br.[C:24](=[O:27])([O-:26])[O-:25].[K+].[K+]>CC(C)=O>[N:2]1[CH:7]=[CH:6][C:5]([C:8]([O:10][CH2:15][C:16]2[O:20][C:19](=[O:21])[O:18][C:17]=2[CH3:22])=[O:9])=[CH:4][C:3]=1[C:11]([O:13][CH2:11][C:3]1[O:27][C:24](=[O:26])[O:25][C:4]=1[CH3:5])=[O:12]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 107741414-(Bromomethyl)-5-methyl-1,3-dioxol-2-oneHCID 67883991HCID 67883991, compound

Product 1

HCID 14210546HCID 14210546, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

6.3 g of-pyridine-2,4-dicarboxylic acid sodium salt are boiled under reflux with 14.3 g of 5-methyl-2-oxo-1,3-dioxol-4-yl-methyl bromide and 4.5 g of potassium carbonate in 125 ml of dry acetone for 40 hours. The carbonate is filtered off and the solution is chromatographed over silica gel with a 4:1 mixture of toluene and ethyl acetate.

Workup

  1. filtrationThe carbonate is filtered off
  2. customthe solution is chromatographed over silica gel with a 4:1 mixture of toluene and ethyl acetate

Sources & evidence

ORD record
ord-4f0902ffc70a4d03a9316f9b2c89165c
Source dataset
uspto-grants-1994_11
Patent number
US05364873

Reaction notes

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