Hydrochloric Acid → HCID 69963225, compound

HRID 2379779Notes

Reaction equation

HRID 2379779 reaction equation
[C:1]1([CH2:10][C:11]([OH:13])=[O:12])[O:2][CH:3]=[C:4]2[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=12.Cl.[CH3:15]O>>[C:1]1([CH2:10][C:11]([O:13][CH3:15])=[O:12])[O:2][CH:3]=[C:4]2[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=12

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 20325024HCID 20325024, compound

Product 1

HCID 69963225HCID 69963225, compound

Procedure

Compound 7 (72 g) was dissolved in methanol (200 ml) and the solution saturated with dry HCl. The solution was refluxed for 2 hours and the solvent evaporated. The residue was dissolved in methylene chloride (200 ml) and the solution washed with 5% sodium bicarbonate, and then with water (100 ml). The residue was dried over magnesium sulfate and the solvent was evaporated. The product was distilled in vacuo. The yield was approximately 67.3 g.

Workup

  1. temperatureThe solution was refluxed for 2 hours
  2. customthe solvent evaporated
  3. dissolutionThe residue was dissolved in methylene chloride (200 ml)
  4. washthe solution washed with 5% sodium bicarbonate
  5. dry with materialThe residue was dried over magnesium sulfate
  6. customthe solvent was evaporated
  7. distillationThe product was distilled in vacuo

Sources & evidence

ORD record
ord-30d48661dd9842f4bb7820564893488b
Source dataset
uspto-grants-1994_11
Patent number
US05364880

Reaction notes

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