反应详情

Compound 7 (72 g) was dissolved in methanol (200 ml) and the solution saturated with dry HCl. The solution was refluxed for 2 hours and the solvent evaporated. The residue was dissolved in methylene chloride (200 ml) and the solution washed with 5% sodium bicarbonate, and then with water (100 ml). The residue was dried over magnesium sulfate and the solvent was evaporated. The product was distilled in vacuo. The yield was approximately 67.3 g.

1. temperatureThe solution was refluxed for 2 hours
2. customthe solvent evaporated
3. dissolutionThe residue was dissolved in methylene chloride (200 ml)
4. washthe solution washed with 5% sodium bicarbonate
5. dry with materialThe residue was dried over magnesium sulfate
6. customthe solvent was evaporated
7. distillationThe product was distilled in vacuo