Hydrochloric Acid → HCID 178472554, compound

HRID 2379791Notes

Reaction equation

HRID 2379791 reaction equation
[C:1]([NH:9][C@H:10]([C:18]([OH:20])=[O:19])[CH2:11][CH2:12][CH2:13][NH:14][C:15](=[NH:17])[NH2:16])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:21](O)[CH3:22].Cl.[Cl:25]CCl>CO>[ClH:25].[CH2:21]([O:19][C:18](=[O:20])[C@H:10]([CH2:11][CH2:12][CH2:13][NH:14][C:15](=[NH:16])[NH2:17])[NH:9][C:1](=[O:8])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1)[CH3:22]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 6344DichloromethaneHCID 178512846HCID 178512846, compound2×

Product 1

HCID 178472554HCID 178472554, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Nα -benzoyl-L-arginine was obtained from MTM Research Chemicals, Lancaster Synthesis, Inc., Windham, N.H. The Nα -benzoyl-L-arginine, 0.4 g, was placed in a two-necked round bottom flask equipped with a stirring bar and suspended in an excess (~5 ml) of ethyl alcohol. The outlet from the flask was attached to a mineral oil bubbler and dry hydrogen chloride gas was bubbled via the inlet into the stirred solution to the point of saturation; a mildly exothermic reaction ensued with gradual dissolution of the suspended starting material. The reaction was monitored by thin layer chromatography (TLC) in solvent system (dichloromethane:methanol: 80:20; v/v) until no starting material was left.

Workup

  1. customequipped with a stirring bar
  2. customwas bubbled via the inlet into the stirred solution to the point of saturation
  3. customa mildly exothermic reaction
  4. dissolutionensued with gradual dissolution of the suspended
  5. waitwas left

Sources & evidence

ORD record
ord-115a10ffb40a4bdcadbea64999864a96
Source dataset
uspto-grants-1994_11
Patent number
US05364884

Reaction notes

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