Ammonia → 3-Pyridinecarboxamide, 5-acetyl-

HRID 2379821Notes

Reaction equation

HRID 2379821 reaction equation
C[O:2][C:3]([C:5]1[CH:6]=[N:7][CH:8]=[C:9]([C:11](=[O:13])[CH3:12])[CH:10]=1)=O.[NH3:14]>>[C:11]([C:9]1[CH:8]=[N:7][CH:6]=[C:5]([C:3](=[O:2])[NH2:14])[CH:10]=1)(=[O:13])[CH3:12]

Participants

3

Reactant 2

HCID 222AmmoniaHCID 596459Methyl 5-acetylpyridine-3-carboxylate

Product 1

HCID 226073883-Pyridinecarboxamide, 5-acetyl-

Procedure

A suspension of 5-acetyl-3-pyridinecarboxylic acid methyl ester (5.0 g) in 28% ammonia solution (30 ml) was stirred at room temperature for 2 hours. The resulting precipitate was collected by filtration to afford 3-acetyl-5-carbamoylpyridine (3.38 g).

Workup

  1. filtrationThe resulting precipitate was collected by filtration

Sources & evidence

ORD record
ord-d1cd05bb777243bc8999f460bbe1c019
Source dataset
uspto-grants-1994_11
Patent number
US05364871

Reaction notes

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