Ethyl Acetate → HCID 54166508, compound

HRID 2379823Notes

Reaction equation

HRID 2379823 reaction equation
[C:1]([NH:4][CH2:5][C:6]1[N:11]=[C:10]([C:12]2[N:13]=[C:14]([NH2:17])[S:15][CH:16]=2)[CH:9]=[CH:8][CH:7]=1)(=[O:3])[CH3:2].[CH3:18][N:19]=[C:20]=[S:21].C(OCC)(=O)C>C(O)C>[C:1]([NH:4][CH2:5][C:6]1[N:11]=[C:10]([C:12]2[N:13]=[C:14]([NH:17][C:20]([NH:19][CH3:18])=[S:21])[S:15][CH:16]=2)[CH:9]=[CH:8][CH:7]=1)(=[O:3])[CH3:2]

Participants

5

Reactant 3

HCID 8857Ethyl AcetateHCID 11167Methyl isothiocyanateHCID 10944783HCID 10944783, compound

Product 1

HCID 54166508HCID 54166508, compoundYield 20.7%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 4-(6-acetylaminomethylpyridin-2-yl)2-aminothiazole (7.0 g) and methyl isothiocyanate (6.2 g) in ethanol (140 ml) was heated under reflux for 40 minutes and then the mixture was cooling to ambient temperature. To the mixture was added ethyl acetate (140 ml) and isolated precipitate was collected by filtration to give 4-(6-acetylaminomethylpyridin-2-yl)-2-(3-methylthioureido)thiazole (1.88 g).

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for 40 minutes
  3. customisolated precipitate
  4. filtrationwas collected by filtration

Sources & evidence

ORD record
ord-8efcd8536de6414aa9c3211cddf58c9b
Source dataset
uspto-grants-1994_11
Patent number
US05364871

Reaction notes

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