Methyl iodide → HCID 86748245, compound

HRID 2379831Notes

Reaction equation

HRID 2379831 reaction equation
[C:1]([NH:5][CH2:6][C:7]1[N:12]=[C:11]([C:13]2[N:14]=[C:15]([NH:18][C:19]([NH2:21])=[S:20])[S:16][CH:17]=2)[CH:10]=[CH:9][CH:8]=1)(=[O:4])[CH2:2][CH3:3].[CH3:22][I:23]>CO>[IH:23].[NH2:21][C:19](=[N:18][C:15]1[S:16][CH:17]=[C:13]([C:11]2[CH:10]=[CH:9][CH:8]=[C:7]([CH2:6][NH:5][C:1](=[O:4])[CH2:2][CH3:3])[N:12]=2)[N:14]=1)[S:20][CH3:22]

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 18956285HCID 18956285, compound

Product 1

HCID 86748245HCID 86748245, compoundYield 64.7%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A suspension of 4-(6-propionylaminomethylpyridin-2-yl)-2-thioureidothiazole (14.67 g) and methyl iodide (7.77 g) in methanol (300 ml) was refluxed for 3 hours. The solvent was removed under reduced pressure. The residue was crystallized from ethyl acetate to afford 2-[(amino)(methylthio)methyleneamino]-4-(6-propionylaminomethylpyridin-2-yl)thiazole hydriodide (13.68 g).

Workup

  1. temperaturewas refluxed for 3 hours
  2. customThe solvent was removed under reduced pressure
  3. customThe residue was crystallized from ethyl acetate

Sources & evidence

ORD record
ord-e79c705d3df44ed18a8d52a10adf3f2a
Source dataset
uspto-grants-1994_11
Patent number
US05364871

Reaction notes

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