反应详情

Concentrated hydrochloric acid (72.4 ml) was added slowly to a suspension of 4-(2-acetylaminomethylthiazol-4-yl)-2-(diaminomethyleneamino)thiazole (6.58 g) in ethanol (280 ml). The mixture was refluxed for 2 hours. The resulting precipitate was collected by filtration. Recrystallization from a mixture of methanol and water afforded 4-(2-aminomethylthiazol-4-yl)-2-(diaminomethyleneamino)thiazole dihydrochloride (6.98 g).

1. temperatureThe mixture was refluxed for 2 hours
2. filtrationThe resulting precipitate was collected by filtration
3. customRecrystallization
4. additionfrom a mixture of methanol and water