Water → HCID 67821024, compound

HRID 2379865Notes

Reaction equation

HRID 2379865 reaction equation
[NH2:1][C:2](=[N:4][C:5]1[S:6][CH:7]=[C:8]([C:10]2[NH:11][C:12](=[NH:19])[CH:13]=[CH:14][C:15]=2[CH2:16]OC)[N:9]=1)[NH2:3].[S:20]([NH2:24])([NH2:23])(=[O:22])=[O:21].O>COCCO>[NH2:19][C:12]1[N:11]=[C:10]([C:8]2[N:9]=[C:5]([N:4]=[C:2]([NH2:3])[NH2:1])[S:6][CH:7]=2)[C:15]([CH:16]=[N:23][S:20]([NH2:24])(=[O:22])=[O:21])=[CH:14][CH:13]=1

Participants

5

Reactant 3

HCID 962WaterHCID 82267SulfamideHCID 178494524HCID 178494524, compound

Product 1

HCID 67821024HCID 67821024, compoundYield 49.8%

Reagents, catalysts & solvents 1

HCID 80192-MethoxyethanolSolvent

Procedure

A mixture of 2-(diaminomethyleneamino)-4-[6-(imino)(methoxy)methylpyridin-2-yl]thiazole (2.1 g) and sulfamide (2.9 g) in 2-methoxyethanol (10.5 ml) was stirred for 3 hours at 70°-75° C. The mixture was added to water, isolated precipitate was collected by filtration and dried. The precipitate was recrystallized from a mixture of N,N-dimethylformamide and ethyl acetate to give 4-[6-(amino)(aminosulfonylimino)methylpyridin-2-yl]-2-(diaminomethyleneamino)thiazole (1.28 g).

Workup

  1. customisolated precipitate
  2. filtrationwas collected by filtration
  3. customdried
  4. customThe precipitate was recrystallized from a mixture of N,N-dimethylformamide and ethyl acetate

Sources & evidence

ORD record
ord-b5ed624747094b26ac7811b174f1d959
Source dataset
uspto-grants-1994_11
Patent number
US05364871

Reaction notes

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