Sodium Hydroxide → HCID 18953875, compound

HRID 2379879Notes

Reaction equation

HRID 2379879 reaction equation
[OH-:1].[Na+].Br.[C:4]([C:6]1[CH:11]=[CH:10][N:9]=[C:8]([C:12]2[N:13]=[C:14]([N:17]=[C:18]([NH2:20])[NH2:19])[S:15][CH:16]=2)[CH:7]=1)#[N:5]>CO.O1CCCC1>[C:4]([C:6]1[CH:11]=[CH:10][N:9]=[C:8]([C:12]2[N:13]=[C:14]([N:17]=[C:18]([NH2:20])[NH2:19])[S:15][CH:16]=2)[CH:7]=1)(=[O:1])[NH2:5]

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 18953795HCID 18953795, compound

Product 1

HCID 18953875HCID 18953875, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

1N-Aqueous sodium hydroxide (10 ml) was added to a suspension of 4-(4-cyanopyridin-2-yl)-2-(diaminomethyleneamino)thiazole hydrobromide (1.00 g) in a mixture of methanol (10 ml) and tetrahydrofuran (10 ml). After the mixture was stirred for one day at ambient temperature, the solvent was evaporated in vacuo and the residue was mixed with water (10 ml). The resulting precipitate was collected by filtration, washed with water and recrystallized from a mixture of N,N-dimethylformamide and water to give 4-(4-carbamoylpyridin-2-yl)-2-(diaminomethyleneamino)thiazole (0.45 g).

Workup

  1. customthe solvent was evaporated in vacuo
  2. additionthe residue was mixed with water (10 ml)
  3. filtrationThe resulting precipitate was collected by filtration
  4. washwashed with water
  5. customrecrystallized from a mixture of N,N-dimethylformamide and water

Sources & evidence

ORD record
ord-5c852256b834470db2a7f54998ebb19c
Source dataset
uspto-grants-1994_11
Patent number
US05364871

Reaction notes

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