Hydrazine hydrate (1:1) → HCID 10060571, compound

HRID 2379881Notes

Reaction equation

HRID 2379881 reaction equation
[NH2:1][C:2](=[N:4][C:5]1[S:6][CH:7]=[C:8]([C:10]2[CH:15]=[CH:14][N:13]=[C:12]([CH2:16][N:17]3C(=O)C4=CC=CC=C4C3=O)[CH:11]=2)[N:9]=1)[NH2:3].O.NN>C(O)C>[NH2:17][CH2:16][C:12]1[CH:11]=[C:10]([C:8]2[N:9]=[C:5]([N:4]=[C:2]([NH2:3])[NH2:1])[S:6][CH:7]=2)[CH:15]=[CH:14][N:13]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 10474781HCID 10474781, compound

Product 1

HCID 10060571HCID 10060571, compoundYield 97.1%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 2-(diaminomethyleneamino)-4-(2-phthalimidomethylpyridin-4-yl)thiazole (1.57 g) and hydrazine hydrate (0.63 g) in ethanol (25 ml) was refluxed for two hours. The resulting precipitate was filtered off and washed with methanol (20 ml). The two organic layer was combined and evaporated in vacuo to give 4-(2-aminomethylpyridin-4-yl)-2-(diaminomethyleneamino)thiazole (1.00 g).

Workup

  1. temperaturewas refluxed for two hours
  2. filtrationThe resulting precipitate was filtered off
  3. washwashed with methanol (20 ml)
  4. customevaporated in vacuo

Sources & evidence

ORD record
ord-867df28f6c054af8bf6befff6a2060e7
Source dataset
uspto-grants-1994_11
Patent number
US05364871

Reaction notes

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