HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → HCID 18953852, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 2-(Diaminomethyleneamino)-4-(5-methoxycarbonylpyridin-3-yl)thiazole | HCID 10468734 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 18953852 | HCID 18953852 | — |
Reaction Steps
A suspension of 2-(diaminomethyleneamino)-4-(5-methoxycarbonylpyridin-3-yl)thiazole (500 mg) in 28% ammonia solution (15 ml) and tetrahydrofuran (15 ml) was stirred at room temperature for 9.5 hours. The solvent was removed under reduced pressure. The residue was washed with methanol to afford 4-(5-carbamoylpyridin-3-yl)-2-(diaminomethyleneamino)thiazole (350 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05364871 |
| Source dataset | uspto-grants-1994_11 |
| ORD ID | ord-289801da48534091bf8a2649f27de213 |
| Source note | uspto-grants-1994_11 |