Ammonia → HCID 18953852, compound

HRID 2379883Notes

Reaction equation

HRID 2379883 reaction equation
[NH2:1][C:2](=[N:4][C:5]1[S:6][CH:7]=[C:8]([C:10]2[CH:11]=[N:12][CH:13]=[C:14]([C:16]([O:18]C)=O)[CH:15]=2)[N:9]=1)[NH2:3].[NH3:20]>O1CCCC1>[C:16]([C:14]1[CH:15]=[C:10]([C:8]2[N:9]=[C:5]([N:4]=[C:2]([NH2:3])[NH2:1])[S:6][CH:7]=2)[CH:11]=[N:12][CH:13]=1)(=[O:18])[NH2:20]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 104687342-(Diaminomethyleneamino)-4-(5-methoxycarbonylpyridin-3-yl)thiazole

Product 1

HCID 18953852HCID 18953852, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A suspension of 2-(diaminomethyleneamino)-4-(5-methoxycarbonylpyridin-3-yl)thiazole (500 mg) in 28% ammonia solution (15 ml) and tetrahydrofuran (15 ml) was stirred at room temperature for 9.5 hours. The solvent was removed under reduced pressure. The residue was washed with methanol to afford 4-(5-carbamoylpyridin-3-yl)-2-(diaminomethyleneamino)thiazole (350 mg).

Workup

  1. customThe solvent was removed under reduced pressure
  2. washThe residue was washed with methanol

Sources & evidence

ORD record
ord-289801da48534091bf8a2649f27de213
Source dataset
uspto-grants-1994_11
Patent number
US05364871

Reaction notes

Loading…