Bromochloromethane → HCID 18956522, compound

HRID 2380048Notes

Reaction equation

HRID 2380048 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9](=[O:18])[CH:10]([C:12]1[N:13]=[N:14][CH:15]=[CH:16][CH:17]=1)[CH3:11].Br[CH2:20]Cl.C([Li])CCC>CCCCCC>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1([CH:10]([C:12]2[N:13]=[N:14][CH:15]=[CH:16][CH:17]=2)[CH3:11])[CH2:20][O:18]1

Participants

5

Reactant 3

HCID 6333BromochloromethaneHCID 18956523HCID 18956523, compoundHCID 178418339Butyllithium

Product 1

HCID 18956522HCID 18956522, compoundYield 56.8%

Reagents, catalysts & solvents 1

HCID 8058HexaneSolvent

Procedure

Treatment of the product of part (ii) (2.0 g) with bromochloromethane (1.15 g) and n-butyllithium (5.28 ml of a 1.6M solution in hexane) according to the method of Example 11(iii) gave the title compound as a gum (1.20 g) which was used directly in the next stage.

Sources & evidence

ORD record
ord-111926274c414aa99d64d4644270f641
Source dataset
uspto-grants-1994_11
Patent number
US05364938

Reaction notes

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