HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hexane → HCID 18956534, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hexane | HCID 8058 | — |
| Reactant | 2-Methylpyrimidine | HCID 78748 | — |
| Reactant | Lithium diisopropylamide | HCID 2724682 | — |
| Reactant | Methyl 2,4-Difluorobenzoate | HCID 2782897 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 18956534 | HCID 18956534 | 16.4% |
Reaction Steps
Treatment of 2-methylpyrimidine (8.50 g) with lithium diisopropylamide (0.09 mole) in dry tetrahydrofuran followed by methyl 2,4-difluorobenzoate (15.5 g) according to the method of Example 11(i) gave the title compound (3.45 g), m.p. 86°-88° (from hexane).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05364938 |
| Source dataset | uspto-grants-1994_11 |
| ORD ID | ord-a6a9cfb36bb54e8f9467637562df446e |
| Source note | uspto-grants-1994_11 |