Methyl iodide → 1-(2,4-Difluorophenyl)-2-(pyridin-3-yl)propan-1-one

HRID 2380054Notes

Reaction equation

[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9](=[O:17])[CH2:10][C:11]1[CH:12]=[N:13][CH:14]=[CH:15][CH:16]=1.I[CH3:19]>>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9](=[O:17])[CH:10]([C:11]1[CH:12]=[N:13][CH:14]=[CH:15][CH:16]=1)[CH3:19]

Participants

Reactant 2

HCID 6328Methyl iodide

HCID 189565241-(2,4-Difluorophenyl)-2-(3-pyridinyl)-ethanone

Product 1

HCID 189565411-(2,4-Difluorophenyl)-2-(pyridin-3-yl)propan-1-oneYield 73.6%

Procedure

Methylation of the product of part (i) (5.0 g) with iodomethane (7.60 g) according to the method of Example 11(ii) gave the title compound as an oil (3.90 g) which was used directly in the next stage.

Sources & evidence

ORD record: ord-5b211545779f4b3996fbdab503582604
Source dataset: uspto-grants-1994_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05364938

Reaction notes

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