HCID 610466, compound → HCID 18956696, compound

Participants

Reaction Steps

The 4-nitro-2',4'-dimethylbenzophenone obtained in b) was mixed with 900 ml of isobutanol and 3.5 g of activated nickel powder and hydrogenated under a slight superatmospheric pressure (1.25 bar) of hydrogen at 50°-60° C. to give 4-amino-2',4'-dimethylbenzophenone. The catalyst was filtered off and then the organic solvent was distilled off to recover it, and water at 95° C. was added to the residue at 100°-110° C. and the mixture was stirred until room temperature was reached. 4-Amino-2',4'-dimethylbenzophenone crystallized out at 90° C. The crystalline product was filtered off with suction, washed with water and dried. 215 g of amino compound (melting point 121° C.) were obtained.

Provenance & Evidence