HCID 610466, compound → HCID 18956696, compound

HRID 2380092Notes

Reaction equation

HRID 2380092 reaction equation
[N+:1]([C:4]1[CH:19]=[CH:18][C:7]([C:8]([C:10]2[CH:15]=[CH:14][C:13]([CH3:16])=[CH:12][C:11]=2[CH3:17])=[O:9])=[CH:6][CH:5]=1)([O-])=O.[H][H]>[Ni].C(O)C(C)C>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]([C:8]([C:10]2[CH:15]=[CH:14][C:13]([CH3:16])=[CH:12][C:11]=2[CH3:17])=[O:9])=[CH:18][CH:19]=1

Participants

5

Reactant 2

HCID 610466HCID 610466, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 18956696HCID 18956696, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 6560IsobutanolSolvent

Procedure

The 4-nitro-2',4'-dimethylbenzophenone obtained in b) was mixed with 900 ml of isobutanol and 3.5 g of activated nickel powder and hydrogenated under a slight superatmospheric pressure (1.25 bar) of hydrogen at 50°-60° C. to give 4-amino-2',4'-dimethylbenzophenone. The catalyst was filtered off and then the organic solvent was distilled off to recover it, and water at 95° C. was added to the residue at 100°-110° C. and the mixture was stirred until room temperature was reached. 4-Amino-2',4'-dimethylbenzophenone crystallized out at 90° C. The crystalline product was filtered off with suction, washed with water and dried. 215 g of amino compound (melting point 121° C.) were obtained.

Sources & evidence

ORD record
ord-f9555fbbdda743e0abbcfce3dfa25f94
Source dataset
uspto-grants-1994_11
Patent number
US05364972

Reaction notes

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