HRID2380138

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID74089

Valeryl chloride, 5-chloro-

C5H8Cl2O

HCID10087530

未命名化合物

结构：N#CCCCCN(OCc1ccccc1)C(=O)CCCCNOCc1ccccc1

HCID10341465

未命名化合物

PRODUCTS

生成物

结构：N#CCCCCN(OCc1ccccc1)C(=O)CCCCN(OCc1ccccc1)C(=O)CCCCCl

HCID11756691

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6344

Dichloromethane

CH2Cl2

溶剂HCID14798

Sodium Hydroxide

HNaO

PROCEDURE

实验过程

Compound (5) (2.44 g, 5.96 mmol) was reacted with 5-chlorovaleryl chloride (1.13 g, 7.29 mmol) in CH2Cl2 (150 mL) and 1N NaOH (200 mL) by the procedure used for (3). Silica gel column chromatography, eluting with 3% EtOH/CHCl3, gave (6) in quantitative yield as an oil: NMR δ 1.50-1.87 (m, 12H), 2.23-2.53 (m, 6H), 3.47 (t, 2H, J=6), 3.60 (t, 4H, J=6), 4.77 (s, 4H) , 7.33 (s, 10H) . Anal. (C29H38ClN3O4) C, H, N.

WORKUP

后处理

washSilica gel column chromatography, eluting with 3% EtOH/CHCl3

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-266f5f1a026846fbaeb9ca936a8e3b98
来源数据集: uspto-grants-1994_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05364965
来源说明: uspto-grants-1994_11

反应 SMILES

[CH2:1]([O:8][N:9]([C:16](=[O:30])[CH2:17][CH2:18][CH2:19][CH2:20][NH:21][O:22][CH2:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)[CH2:10][CH2:11][CH2:12][CH2:13][C:14]#[N:15])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl:31][CH2:32][CH2:33][CH2:34][CH2:35][C:36](Cl)=[O:37].C(ON(CCCCC#N)C(=O)CCCCCl)C1C=CC=CC=1>C(Cl)Cl.[OH-].[Na+]>[Cl:31][CH2:32][CH2:33][CH2:34][CH2:35][C:36](=[O:37])[N:21]([O:22][CH2:23][C:24]1[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=1)[CH2:20][CH2:19][CH2:18][CH2:17][C:16](=[O:30])[N:9]([O:8][CH2:1][C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1)[CH2:10][CH2:11][CH2:12][CH2:13][C:14]#[N:15]