HuagongsheHuagongshe Chemistry Print Report · For research reference only
Decanoyl chloride → 6,12,18-Tris(benzyloxy)-7,13,19-trioxo-6,12,18-triazaoctacosanenitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Decanoyl chloride | HCID 66982 | — |
| Reactant | 6,12,18-Tris(benzyloxy)-7,13-dioxo-6,12,18-triazaoctadecanenitrile | HCID 9986266 | — |
| Reactant | N-(Benzyloxy)-N-(4-cyanobutyl)-5-chloropentanamide | HCID 10087530 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | Sodium Hydroxide | HCID 14798 | — |
| Product | 6,12,18-Tris(benzyloxy)-7,13,19-trioxo-6,12,18-triazaoctacosanenitrile | HCID 10417720 | 80% |
Reaction Steps
Compound (8) (1.20 g, 1.95 mmol) was reacted with decanoyl chloride (0.565 g, 2.96 mmol) in CH2Cl2 and 1N NaOH following the procedure used for (3). Purification by silica gel column chromatography with 2:1 EtOAc/hexane as the eluant provided 1.20 g (80%) of (10) as an oil: NMR δ 0.90 (t, 3H, J=6), 1.13-1.40 (m, 14H), 1.47-1.90 (m, 12H), 2.23-2.53 (m, 8H), 3.50-3.77 (m, 6H), 4.77 (s, 6H), 7.33 (s, 15H). Anal. (C46H64N4O6) C, H, N.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05364965 |
| Source dataset | uspto-grants-1994_11 |
| ORD ID | ord-e7a8532f85b24f89ae537786c1004578 |
| Source note | uspto-grants-1994_11 |