HCID 9948054, compound → HCID 15056589, compound

HRID 2380212Notes

Reaction equation

HRID 2380212 reaction equation
[N:1]1[C:6]([P:11]([OH:14])(=[O:13])[OH:12])([P:7]([OH:10])(=[O:9])[OH:8])[CH2:5][CH2:4][N:3]2[CH:15]=[CH:16][CH:17]=[CH:18][C:2]=12.[H][H]>O.O=[Pt]=O>[N:1]1[C:6]([P:7]([OH:10])(=[O:8])[OH:9])([P:11]([OH:14])(=[O:12])[OH:13])[CH2:5][CH2:4][N:3]2[CH2:15][CH2:16][CH2:17][CH2:18][C:2]=12

Participants

5

Reactant 2

HCID 9948054HCID 9948054, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 15056589HCID 15056589, compound

Reagents, catalysts & solvents 2

HCID 345198Adams' catalystCatalystHCID 962WaterSolvent

Procedure

3 g of the diphosphonic acid obtained in Example 1 were dissolved in 250 ml water and, after addition of 1.5 g PtO2, hydrogenated at atmospheric pressure up to the take-up of the calculated amount of hydrogen. After separation off of the catalyst and evaporation in a vacuum, the residue was brought to crystallisation from water/acetone. Mrel. 0.33, yield 2.61 g (85% of theory), m.p. 279°-285° C. (decomp.).

Workup

  1. customAfter separation
  2. customoff of the catalyst and evaporation in a vacuum
  3. customthe residue was brought to crystallisation from water/acetone

Sources & evidence

ORD record
ord-9f7bd346a9b74c0ab2e24c1eed7c26d2
Source dataset
uspto-grants-1994_11
Patent number
US05366969

Reaction notes

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