反应详情

Sodium acetate (1.6 g) was added to a solution of 5-amino-2-methoxypyridine (2.5 g) in acetic acid (15 ml). To the resulting solution bromine (3.0 g) was added dropwise, and the mixture was stirred for 20 min., and then added to a solution of sodium hydroxide (10 g) in water (100 ml). The product was extracted with ethyl acetate (50 ml), dried (anhydrous magnesium sulfate), and concentrated in vacuo. The product was purified over a silica gel column (ethyl acetate/hexane, 1:4) to give 2.7 g of the title compound, suitable for use in the next reaction.

1. extractionThe product was extracted with ethyl acetate (50 ml)
2. dry with materialdried (anhydrous magnesium sulfate)
3. concentrationconcentrated in vacuo
4. customThe product was purified over a silica gel column (ethyl acetate/hexane, 1:4)