Sodium Hydroxide → 2-Chloro-6-(imidazol-1-yl)-4-methylpyridine-3-carboxamide

HRID 2380263ノート

反応式

HRID 2380263 の反応式
[Cl:1][C:2]1[C:7]([C:8]#[N:9])=[C:6]([CH3:10])[CH:5]=[C:4]([N:11]2[CH:15]=[CH:14][N:13]=[CH:12]2)[N:3]=1.[OH-].[Na+].C(=O)(O)[O-:19].[Na+]>S(=O)(=O)(O)O.O>[Cl:1][C:2]1[C:7]([C:8]([NH2:9])=[O:19])=[C:6]([CH3:10])[CH:5]=[C:4]([N:11]2[CH:15]=[CH:14][N:13]=[CH:12]2)[N:3]=1

参加物

6

反応物 3

HCID 14798Sodium HydroxideHCID 516892Sodium BicarbonateHCID 199600342-Chloro-3-cyano-6-(imidazol-1-yl)-4-methylpyridine

生成物 1

HCID 199600712-Chloro-6-(imidazol-1-yl)-4-methylpyridine-3-carboxamide

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 1118Sulfuric Acid溶媒

実験手順

A solution of 2-chloro-3-cyano-6-(imidazol-1-yl)-4-methylpyridine (2.1 g) in concentrated sulfuric acid (5 mL) was heated at 130° C. for 15 minutes. The mixture was cooled to room temperature, diluted with water (10 mL), and adjusted to pH 7 with 20% sodium hydroxide solution followed by solid sodium bicarbonate. The crystalline product was removed by filtration and dried to give 2.35 g of the title compound, suitable for use in the next reaction.

後処理

  1. customThe crystalline product was removed by filtration
  2. customdried

出典と根拠

ORDレコード
ord-b478aff870d8496792891a73a2ff8a4b
出典データセット
uspto-grants-1994_11
特許番号
US05366972

反応ノート

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