1H-1,2,4-Triazole → HCID 86748267, compound

HRID 2380275Notes

Reaction equation

HRID 2380275 reaction equation
[CH3:1][C:2]([CH3:17])([CH3:16])[CH2:3][CH2:4][O:5][C:6]1[CH:7]=[C:8]([CH:13]=[CH:14][CH:15]=1)[C:9](Cl)=[N:10][OH:11].[NH:18]1[CH:22]=[N:21][CH:20]=[N:19]1.C(=O)([O-])[O-].[K+].[K+]>COCCOC>[CH3:1][C:2]([CH3:17])([CH3:16])[CH2:3][CH2:4][O:5][C:6]1[CH:7]=[C:8]([CH:13]=[CH:14][CH:15]=1)[C:9]([N:18]1[CH:22]=[N:21][CH:20]=[N:19]1)=[N:10][OH:11]

Participants

5

Reactant 3

HCID 92571H-1,2,4-TriazoleHCID 11430Potassium CarbonateHCID 85664902HCID 85664902, compound

Product 1

HCID 86748267HCID 86748267, compoundYield 46%

Reagents, catalysts & solvents 1

HCID 80711,2-DimethoxyethaneSolvent

Conditions

Temperature
50 °C

Procedure

To 100 ml of 1,2-dimethoxyethane were added 2.0 g (7.8 mmol) of 3-(3,3-dimethylbutoxy)benzohydroximoyl chloride, 1.9 g (27.5 mmol) of 1,2,4-triazole, and 1.5 g (10.9 mmol) of potassium carbonate. The mixture was stirred for 8 hours at about 50° C. After the resultant mixture was allowed to sit and cool naturally, the solvent in the mixture was removed. The residue was purified by column chromatography, thus obtaining the desired product of 1.2 g (yield: 46% ) .

Workup

  1. temperaturecool naturally
  2. customthe solvent in the mixture was removed
  3. customThe residue was purified by column chromatography

Sources & evidence

ORD record
ord-bdd73a8af3c543cbacef0a2bc804defd
Source dataset
uspto-grants-1994_11
Patent number
US05366988

Reaction notes

Loading…