HCID 86748270, compound → HCID 85664898, compound

HRID 2380277Notes

Reaction equation

HRID 2380277 reaction equation
[CH:1]([O:4][N:5]=[C:6]([N:21]1[CH:25]=[N:24][CH:23]=[N:22]1)[C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([O:13]CC2C=CC=CC=2)[CH:8]=1)([CH3:3])[CH3:2]>[C].[Pd].C(OCC)(=O)C>[CH:1]([O:4][N:5]=[C:6]([N:21]1[CH:25]=[N:24][CH:23]=[N:22]1)[C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([OH:13])[CH:8]=1)([CH3:3])[CH3:2]

Participants

4

Reactant 1

HCID 86748270HCID 86748270, compound

Product 1

HCID 85664898HCID 85664898, compoundYield 89%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 8857Ethyl AcetateSolvent

Procedure

To 150 ml of ethyl acetate were added 5.0 g of 1-(O-isopropyl-3-benzyloxybenzohydroximoyl )-1H-1,2,4-triazole (melting point: 62° C. to 67° C.) And 1 g of 10% palladium carbon at room temperature. In connection with the mixture, the hydrogenolysis reaction was carried out. After 8 hours, the palladium carbon was removed. The filtrate was then concentrated. The residue was purified by column chromatography, thus yielding 3.2 g (yield: 89%) of the desired product having a melting point of 160° C. to 163° C.

Workup

  1. customIn connection with the mixture, the hydrogenolysis reaction
  2. customthe palladium carbon was removed
  3. concentrationThe filtrate was then concentrated
  4. customThe residue was purified by column chromatography

Sources & evidence

ORD record
ord-947fc8f25d624b539f29cc8da5bc9046
Source dataset
uspto-grants-1994_11
Patent number
US05366988

Reaction notes

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