反应详情

To acetic anhydride (0.153 ml) was added formic acid (0.077 ml) at 15°-20° C. The mixture was stirred at ambient temperature for 30 minutes. To this solution was added 4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine (100 mg) under ice-cooling and the mixture was stirred at the same temperature for 1 hour. The reaction mixture was added to a mixture of dichloromethane and aqueous sodium bicarbonate solution. The separated organic layer was dried over magnesium sulfate and evaporated in vacuo to give 4-formyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine (79.9 mg).

1. temperaturecooling
2. stirringthe mixture was stirred at the same temperature for 1 hour
3. dry with materialThe separated organic layer was dried over magnesium sulfate
4. customevaporated in vacuo