HCID 9840196, compound → HCID 178440785, compound

HRID 238031Notes

Reaction equation

HRID 238031 reaction equation
C([N:5]1[C:9]2=[N:10][CH:11]=[N:12][C:13]([NH2:14])=[C:8]2[C:7]([C:15]2[CH:20]=[CH:19][C:18]([C:21]([CH3:24])([CH3:23])[CH3:22])=[CH:17][CH:16]=2)=[N:6]1)(C)(C)C>C(O)=O.Cl>[C:21]([C:18]1[CH:17]=[CH:16][C:15]([C:7]2[C:8]3[C:9](=[N:10][CH:11]=[N:12][C:13]=3[NH2:14])[NH:5][N:6]=2)=[CH:20][CH:19]=1)([CH3:24])([CH3:22])[CH3:23]

Participants

4

Reactant 1

HCID 9840196HCID 9840196, compound

Product 1

HCID 178440785HCID 178440785, compound

Reagents, catalysts & solvents 2

HCID 284Formic AcidSolventHCID 313Hydrochloric AcidSolvent

Procedure

1-tert-butyl-3-(4-tert-butylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine was dissolved in a solution of formic acid (1 mL) and conc. HCl (0.1 mL) and heated to reflux for 2 hours. Reaction was concentrated in vacuo and purified by RP-HPLC (MeCN:H2O:0.1% TFA) to yield ZK125 (quant.). ESI-MS (M+H)+ m/z calcd 268.2, found 268.4.

Workup

  1. temperatureheated
  2. temperatureto reflux for 2 hours
  3. customReaction
  4. concentrationwas concentrated in vacuo
  5. custompurified by RP-HPLC (MeCN:H2O:0.1% TFA)
  6. customto yield ZK125 (quant.)

Sources & evidence

ORD record
ord-2ab731de60b34c93af2da154832f348a
Source dataset
uspto-grants-2014_02
Patent number
US08642604B2

Reaction notes

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