HCID 57692091, compound → HCID 178508709, compound

HRID 238034Notes

Reaction equation

HRID 238034 reaction equation
C([N:5]1[C:9]2=[N:10][CH:11]=[N:12][C:13]([NH2:14])=[C:8]2[C:7]([C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([N+:21]([O-:23])=[O:22])[CH:16]=2)=[N:6]1)(C)(C)C>C(O)=O.Cl>[N+:21]([C:17]1[CH:16]=[C:15]([C:7]2[C:8]3[C:9](=[N:10][CH:11]=[N:12][C:13]=3[NH2:14])[NH:5][N:6]=2)[CH:20]=[CH:19][CH:18]=1)([O-:23])=[O:22]

Participants

4

Reactant 1

HCID 57692091HCID 57692091, compound

Product 1

HCID 178508709HCID 178508709, compound

Reagents, catalysts & solvents 2

HCID 284Formic AcidSolventHCID 313Hydrochloric AcidSolvent

Procedure

1-tert-butyl-3-(3-nitrophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine (23 mg, 0.055 mmol) was dissolved in a solution of formic acid (5 mL) and conc. HCl (0.1 mL) and heated to reflux for 2 hours. Reaction was concentrated in vacuo and purified by RP-HPLC (MeCN:H2O:0.1% TFA). ESI-MS (M+H)+ m/z calcd 257.1, found 257.3.

Workup

  1. temperatureheated
  2. temperatureto reflux for 2 hours
  3. customReaction
  4. concentrationwas concentrated in vacuo
  5. custompurified by RP-HPLC (MeCN:H2O:0.1% TFA)

Sources & evidence

ORD record
ord-c751960bcc86404d9084e11ddfefeaec
Source dataset
uspto-grants-2014_02
Patent number
US08642604B2

Reaction notes

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