HCID 54462246, compound → HCID 10065423, compound

HRID 2380340Notes

Reaction equation

HRID 2380340 reaction equation
[C:1]1([C:7]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[N:10]=[C:9]([CH:17]=[CH:18][CH2:19][CH2:20][CH2:21][CH2:22][C:23]([OH:25])=[O:24])[CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>[Pd].O1CCCC1>[C:1]1([C:7]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[N:10]=[C:9]([CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][C:23]([OH:25])=[O:24])[CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 1

HCID 54462246HCID 54462246, compound

Product 1

HCID 10065423HCID 10065423, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8028TetrahydrofuranSolvent

Procedure

A mixture of 1.75 g of 7-(4-phenyl-2-quinolyl)-6-hepten-1-oic acid, 0.18 g of palladium on activated carbon (10% w/w) and 100 cc of tetrahydrofuran is hydrogenated under normal pressure for 1 hour at room temperature. After filtration and concentration in vacuo, the solid residue is stirred in 100 cc diethyl ether and then recrystallized from 40 cc acetone to give 7-(4-phenyl-2-quinolyl)heptanoic acid as a whitish solid. (m.p.=137°-139° C).

Workup

  1. filtrationAfter filtration and concentration in vacuo
  2. customrecrystallized from 40 cc acetone

Sources & evidence

ORD record
ord-05cec2bc1cea434b89e2a3a54b3cad32
Source dataset
uspto-grants-1994_11
Patent number
US05366982

Reaction notes

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