HCID 57692114, compound → HCID 178508704, compound

HRID 238035Notes

Reaction equation

HRID 238035 reaction equation
C([N:5]1[C:9]2=[N:10][CH:11]=[N:12][C:13]([NH2:14])=[C:8]2[C:7]([C:15]2[CH:16]=[CH:17][C:18]3[O:22][CH2:21][O:20][C:19]=3[CH:23]=2)=[N:6]1)(C)(C)C>C(O)=O.Cl>[O:20]1[C:19]2[CH:23]=[C:15]([C:7]3[C:8]4[C:9](=[N:10][CH:11]=[N:12][C:13]=4[NH2:14])[NH:5][N:6]=3)[CH:16]=[CH:17][C:18]=2[O:22][CH2:21]1

Participants

4

Reactant 1

HCID 57692114HCID 57692114, compound

Product 1

HCID 178508704HCID 178508704, compound

Reagents, catalysts & solvents 2

HCID 284Formic AcidSolventHCID 313Hydrochloric AcidSolvent

Procedure

1-tert-butyl-3-(benzo[d][1,3]dioxol-6-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine (21 mg, 0.082 mmol) was dissolved in a solution of formic acid (1 mL) and conc. HCl (0.2 mL) and heated to reflux for 2 hours. Reaction was concentrated in vacuo and purified by RP-HPLC (MeCN:H2O:0.1% TFA). ESI-MS (M+H)+ m/z calcd 256.1, found 256.3.

Workup

  1. temperatureheated
  2. temperatureto reflux for 2 hours
  3. customReaction
  4. concentrationwas concentrated in vacuo
  5. custompurified by RP-HPLC (MeCN:H2O:0.1% TFA)

Sources & evidence

ORD record
ord-75c7519b8b004272b8068d9534097cc1
Source dataset
uspto-grants-2014_02
Patent number
US08642604B2

Reaction notes

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