HCID 68710664, compound → HCID 178424714, compound

HRID 238038Notes

Reaction equation

HRID 238038 reaction equation
C([N:5]1[C:9]2=[N:10][CH:11]=[N:12][C:13]([NH2:14])=[C:8]2[C:7]([C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([CH3:21])[C:16]=2[CH3:22])=[N:6]1)(C)(C)C>C(O)=O.Cl>[CH3:22][C:16]1[C:17]([CH3:21])=[CH:18][CH:19]=[CH:20][C:15]=1[C:7]1[C:8]2[C:9](=[N:10][CH:11]=[N:12][C:13]=2[NH2:14])[NH:5][N:6]=1

Participants

4

Reactant 1

HCID 68710664HCID 68710664, compound

Product 1

HCID 178424714HCID 178424714, compound

Reagents, catalysts & solvents 2

HCID 284Formic AcidSolventHCID 313Hydrochloric AcidSolvent

Procedure

1-tert-butyl-3-(2,3-dimethylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine (34 mg, 0.14 mmol) was dissolved in a solution of formic acid (2 mL) and conc. HCl (0.2 mL) and heated to reflux for 30 min. Reaction was concentrated in vacuo and purified by RP-HPLC (MeCN:H2O:0.1% TFA). ESI-MS (M+H)+ m/z calcd 240.1, found 240.4.

Workup

  1. temperatureheated
  2. temperatureto reflux for 30 min
  3. customReaction
  4. concentrationwas concentrated in vacuo
  5. custompurified by RP-HPLC (MeCN:H2O:0.1% TFA)

Sources & evidence

ORD record
ord-a179bb0ffc944cbba2d9f69c3d7c1e74
Source dataset
uspto-grants-2014_02
Patent number
US08642604B2

Reaction notes

Loading…