HCID 178442009, compound → HCID 178508707, compound

HRID 238039Notes

Reaction equation

HRID 238039 reaction equation
C([C:5]1([OH:21])[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]1[C:11]1[C:19]2[C:14](=[N:15][CH:16]=[N:17][C:18]=2[NH2:20])[NH:13][N:12]=1)(C)(C)C>C(O)=O.Cl>[NH2:20][C:18]1[N:17]=[CH:16][N:15]=[C:14]2[NH:13][N:12]=[C:11]([C:6]3[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=3[OH:21])[C:19]=12

Participants

4

Reactant 1

HCID 178442009HCID 178442009, compound

Product 1

HCID 178508707HCID 178508707, compound

Reagents, catalysts & solvents 2

HCID 284Formic AcidSolventHCID 313Hydrochloric AcidSolvent

Procedure

1-tert-butyl-2-(4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl)phenol (5 mg, 0.014 mmol) was dissolved in a solution of formic acid (2 mL) and conc. HCl (0.2 mL) and heated to reflux for 30 min. Reaction was concentrated in vacuo and purified by RP-HPLC (MeCN:H2O:0.1% TFA). ESI-MS (M+H)+ m/z calcd 228.1, found 228.3.

Workup

  1. temperatureheated
  2. temperatureto reflux for 30 min
  3. customReaction
  4. concentrationwas concentrated in vacuo
  5. custompurified by RP-HPLC (MeCN:H2O:0.1% TFA)

Sources & evidence

ORD record
ord-a17a9edcd7084846ac1c3b7f38957d27
Source dataset
uspto-grants-2014_02
Patent number
US08642604B2

Reaction notes

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