HCID 59796528, compound → HCID 178507466, compound

HRID 238043Notes

Reaction equation

HRID 238043 reaction equation
C([N:5]1[C:9]2=[N:10][CH:11]=[N:12][C:13]([NH2:14])=[C:8]2[C:7]([C:15]2[CH:20]=[CH:19][C:18]([NH2:21])=[CH:17][CH:16]=2)=[N:6]1)(C)(C)C>C(O)=O.Cl>[NH2:21][C:18]1[CH:19]=[CH:20][C:15]([C:7]2[C:8]3[C:9](=[N:10][CH:11]=[N:12][C:13]=3[NH2:14])[NH:5][N:6]=2)=[CH:16][CH:17]=1

Participants

4

Reactant 1

HCID 59796528HCID 59796528, compound

Product 1

HCID 178507466HCID 178507466, compound

Reagents, catalysts & solvents 2

HCID 284Formic AcidSolventHCID 313Hydrochloric AcidSolvent

Procedure

1-tert-butyl-3-(4-aminophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine (9 mg, 0.032 mmol) was dissolved in a solution of formic acid (1 mL) and conc. HCl (0.2 mL) and heated to reflux. The reaction was allowed to proceed 30 min., then concentrated in vacuo and the products purified by RP-HPLC (MeCN:H2O:0.1% TFA). ESI-MS (M+H)+ m/z calcd 227.1, found 227.3.

Workup

  1. temperatureheated to reflux
  2. concentrationconcentrated in vacuo
  3. customthe products purified by RP-HPLC (MeCN:H2O:0.1% TFA)

Sources & evidence

ORD record
ord-80f8832aad2a4745835597fe397626f1
Source dataset
uspto-grants-2014_02
Patent number
US08642604B2

Reaction notes

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