Ammonia methanol → 5-Iodo-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine

HRID 238045Notes

Reaction equation

HRID 238045 reaction equation
Cl[C:2]1[C:3]2[C:10]([I:11])=[CH:9][N:8]([CH3:12])[C:4]=2[N:5]=[CH:6][N:7]=1.[NH3:13].CO>>[I:11][C:10]1[C:3]2[C:2]([NH2:13])=[N:7][CH:6]=[N:5][C:4]=2[N:8]([CH3:12])[CH:9]=1

Participants

3

Reactant 2

HCID 21705897Ammonia methanolHCID 426094624-chloro-5-iodo-7-methyl-7H-pyrrolo[2,3-d]pyrimidine

Product 1

HCID 594241805-Iodo-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Conditions

Temperature
110 °C

Procedure

4-chloro-5-iodo-7-methyl-7H-pyrrolo[2,3-d]pyrimidine (90 mg, 0.31 mmol) was taken up in 7N NH3/MeOH and heated in a sealed tube at 110° C. overnight. Reaction was concentrated in vacuo to give a brown/off-white solid.

Workup

  1. customReaction
  2. concentrationwas concentrated in vacuo
  3. customto give a brown/off-white solid

Sources & evidence

ORD record
ord-b53e7ab9cf454cf687ef75b9c23fbc95
Source dataset
uspto-grants-2014_02
Patent number
US08642604B2

Reaction notes

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