1-Ter-Butyl-3-P-Tolyl-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine → HCID 178424072, compound

HRID 238046Notes

Reaction equation

HRID 238046 reaction equation
C([N:5]1[C:9]2=[N:10][CH:11]=[N:12][C:13]([NH2:14])=[C:8]2[C:7]([C:15]2[CH:20]=[CH:19][C:18]([CH3:21])=[CH:17][CH:16]=2)=[N:6]1)(C)(C)C>C(O)=O.Cl>[C:18]1([CH3:21])[CH:17]=[CH:16][C:15]([C:7]2[C:8]3[C:9](=[N:10][CH:11]=[N:12][C:13]=3[NH2:14])[NH:5][N:6]=2)=[CH:20][CH:19]=1

Participants

4

Reactant 1

HCID 14001-Ter-Butyl-3-P-Tolyl-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine

Product 1

HCID 178424072HCID 178424072, compound

Reagents, catalysts & solvents 2

HCID 284Formic AcidSolventHCID 313Hydrochloric AcidSolvent

Procedure

1-tert-butyl-3-p-tolyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine was dissolved in a solution of formic acid (1 mL) and conc. HCl (0.1 mL) and heated to reflux. The reaction was allowed to proceed 30 min., then concentrated in vacuo and the products purified by RP-HPLC (MeCN:H2O:0.1% TFA). ESI-MS (M+H)+ m/z calcd 226.1, found 226.3.

Workup

  1. temperatureheated to reflux
  2. concentrationconcentrated in vacuo
  3. customthe products purified by RP-HPLC (MeCN:H2O:0.1% TFA)

Sources & evidence

ORD record
ord-1a789bbbb7d548afb9a8f2d64970054f
Source dataset
uspto-grants-2014_02
Patent number
US08642604B2

Reaction notes

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