Codeine phosphate hydrate → Codeine

HRID 2380552Notes

Reaction equation

HRID 2380552 reaction equation
[CH3:1][N:2]1[C@@H:18]2[CH2:19][C:7]3[CH:8]=[CH:9][C:10]([O:21][CH3:22])=[C:11]4[O:12][C@H:13]5[C@@H:14]([OH:20])[CH:15]=[CH:16][C@@H:17]2[C@:5]5([C:6]=34)[CH2:4][CH2:3]1.O.OP(O)(O)=O>O>[CH3:1][N:2]1[C@@H:18]2[CH2:19][C:7]3[CH:8]=[CH:9][C:10]([O:21][CH3:22])=[C:11]4[O:12][C@H:13]5[C@@H:14]([OH:20])[CH:15]=[CH:16][C@@H:17]2[C@:5]5([C:6]=34)[CH2:4][CH2:3]1

Participants

3

Reactant 1

HCID 9953630Codeine phosphate hydrate

Product 1

HCID 5284371Codeine

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

95.0 g of codeine phosphate was dissolved in 950 ml of deionized water, and 359.9 g of Amberlite IRP 69 was added while stirring. The mixture was stirred for 1 hour. The codeine-resin complex was washed thoroughly in a Buchner funnel, and then dried in a fluidized bed drier for 1 hour at the inlet air temperature of 60° C. to yield a codeine-resin complex. B. Preparation of codeine-resin complex treated with polyethyleneglycol

Workup

  1. addition359.9 g of Amberlite IRP 69 was added
  2. stirringThe mixture was stirred for 1 hour
  3. washThe codeine-resin complex was washed thoroughly in a Buchner funnel
  4. customdried in a fluidized bed drier for 1 hour at the inlet air temperature of 60° C.

Sources & evidence

ORD record
ord-9ebc964dd0bf4226a07cba7b8c6e3edb
Source dataset
uspto-grants-1994_11
Patent number
US05368852

Reaction notes

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