Dextromethorphan hydrobromide monohydrate → Dextromethorphan

HRID 2380555Notes

Reaction equation

HRID 2380555 reaction equation
[CH3:1][N:2]1[C@H:11]2[CH2:12][C:13]3[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[CH:15][C:14]=3[C@:5]3([C@@H:10]2[CH2:9][CH2:8][CH2:7][CH2:6]3)[CH2:4][CH2:3]1.O.Br>O>[CH3:1][N:2]1[C@H:11]2[CH2:12][C:13]3[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[CH:15][C:14]=3[C@:5]3([C@@H:10]2[CH2:9][CH2:8][CH2:7][CH2:6]3)[CH2:4][CH2:3]1

Participants

3

Reactant 1

HCID 5462351Dextromethorphan hydrobromide monohydrate

Product 1

HCID 5360696Dextromethorphan

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

90.0 g of dextromethorphan hydrobromide was dissolved in 900 ml of deionized water, and 378.8 g of Amberlite IRP69 was added while stirring. The mixture was stirred for 1 hour to yield a dextromethorphan-resin complex. Then, the complex was treated with PEG and coated with the diffusion barrier material similarly as in Example 1 to obtain a coated dextromethorphan-resin complex.

Workup

  1. addition378.8 g of Amberlite IRP69 was added
  2. stirringThe mixture was stirred for 1 hour

Sources & evidence

ORD record
ord-a2bb8dbd77254086a8bdf248df9c3cf7
Source dataset
uspto-grants-1994_11
Patent number
US05368852

Reaction notes

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