Dextromethorphan hydrobromide monohydrate → Dextromethorphan

Participants

Reaction Steps

90.0 g of dextromethorphan hydrobromide was dissolved in 900 ml of deionized water, and 378.8 g of Amberlite IRP69 was added while stirring. The mixture was stirred for 1 hour to yield a dextromethorphan-resin complex. Then, the complex was treated with PEG and coated with the diffusion barrier material similarly as in Example 1 to obtain a coated dextromethorphan-resin complex.

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