Pilocarpine Hydrochloride → Pilocarpine

HRID 2380557Notes

Reaction equation

HRID 2380557 reaction equation
[CH3:1][CH2:2][C@@H:3]1[C:7](=[O:8])[O:6][CH2:5][C@@H:4]1[CH2:9][C:10]1[N:14]([CH3:15])[CH:13]=[N:12][CH:11]=1.Cl>O>[CH3:1][CH2:2][C@@H:3]1[C:7](=[O:8])[O:6][CH2:5][C@@H:4]1[CH2:9][C:10]1[N:14]([CH3:15])[CH:13]=[N:12][CH:11]=1

Participants

3

Reactant 1

HCID 5909Pilocarpine Hydrochloride

Product 1

HCID 5910Pilocarpine

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

100.0 g of pilocarpine hydrochloride was dissolved in 900 ml of deionized water, and 300.0 g of Amberlite IRP69 was added while stirring. The mixture was stirred for 1 hour to yield a pilocarpine-resin complex. Then, the complex was treated with PEG and coated with the diffusion barrier material similarly as in Example 1 to obtain a coated pilocarpine-resin complex.

Workup

  1. addition300.0 g of Amberlite IRP69 was added
  2. stirringThe mixture was stirred for 1 hour

Sources & evidence

ORD record
ord-1d8bf16ec7934e62badc329830523566
Source dataset
uspto-grants-1994_11
Patent number
US05368852

Reaction notes

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