Sodium Chloride → HCID 131718784, compound

HRID 2380564Notes

Reaction equation

B([O-])([O-])[O-].[Na+].[Cl-].[NH2:7][C@H:8]([C:13]([NH:15][C@H:16]([C:21]([NH2:23])=[O:22])[CH2:17][CH:18]([CH3:20])[CH3:19])=[O:14])[CH2:9][CH:10]([CH3:12])[CH3:11]>>[NH2:7][C@H:8]([C:13]([NH:15][C@H:16]([C:21]([NH:23][C@H:8]([C:13]([NH2:15])=[O:14])[CH2:9][CH:10]([CH3:12])[CH3:11])=[O:22])[CH2:17][CH:18]([CH3:19])[CH3:20])=[O:14])[CH2:9][C:10]1[CH:11]=[CH:21][CH:16]=[CH:17][CH:12]=1

Participants

Reactant 3

HCID 5234Sodium Chloride

HCID 26574Borate

HCID 7015189L-Leucinamide, L-leucyl-

Product 1

HCID 131718784HCID 131718784, compoundYield 60.3%

Conditions

Temperature: 25 °C

Procedure

2 ml 0.05 borate buffer, pH 9, containing 0.2M NaCl, 2 mMMal-Phe-OMe, 50 mM H-Leu-Leu-NH2 and 12 μM trypsinogen are agitated at 25° C. under pH control. The reaction is stopped as described in Example 1a. After 24 hours, the yield, analytically determined with HPLC, is 61% of theory. A parallel batch resulted, after 48 hours, in a yield of 60.3% of theory.

Workup

customA parallel batch resulted, after 48 hours, in a yield of 60.3% of theory

Sources & evidence

ORD record: ord-46c7ed8af01c40b591ed6f968f3d659c
Source dataset: uspto-grants-1994_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05369018

Reaction notes

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