Dichloromethane → HCID 18954846, compound

HRID 2380660Notes

Reaction equation

HRID 2380660 reaction equation
[C:1]1([CH:7]2[CH2:11][NH:10][N:9]=[C:8]2[C:12]2[CH:17]=[CH:16][C:15]([C:18]([F:21])([F:20])[F:19])=[CH:14][CH:13]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Cl:22][C:23]1[CH:28]=[CH:27][C:26]([N:29]=[C:30]=[S:31])=[CH:25][CH:24]=1.C(Cl)Cl>CCOCC>[Cl:22][C:23]1[CH:28]=[CH:27][C:26]([NH:29][C:30]([N:10]2[CH2:11][CH:7]([C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)[C:8]([C:12]3[CH:17]=[CH:16][C:15]([C:18]([F:20])([F:21])[F:19])=[CH:14][CH:13]=3)=[N:9]2)=[S:31])=[CH:25][CH:24]=1

Participants

5

Reactant 3

HCID 6344DichloromethaneHCID 164804-Chlorophenyl isothiocyanateHCID 18954845HCID 18954845, compound

Product 1

HCID 18954846HCID 18954846, compoundYield 62.2%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

A mixture of 0.7 g of the compound from Step B and 0.41 g of 4-chlorophenyl isothiocyanate were combined in a solvent mixture of 2 mL methylene chloride and 5 mL ether. After stirring overnight the precipitated solids were filtered and dried to afford 0.69 g of the title compound as a white solid, mp 208°-210° C.

Workup

  1. filtrationwere filtered
  2. customdried

Sources & evidence

ORD record
ord-b26d0569b21247fdab6447c23201e03a
Source dataset
uspto-grants-1994_11
Patent number
US05369121

Reaction notes

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