Methyl iodide → HCID 18954835, compound

HRID 2380661Notes

Reaction equation

HRID 2380661 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]([N:11]2[CH2:15][CH:14]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[C:13]([C:22]3[CH:27]=[CH:26][C:25]([C:28]([F:31])([F:30])[F:29])=[CH:24][CH:23]=3)=[N:12]2)=[S:10])=[CH:4][CH:3]=1.I[CH3:33]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]=[C:9]([S:10][CH3:33])[N:11]2[CH2:15][CH:14]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[C:13]([C:22]3[CH:23]=[CH:24][C:25]([C:28]([F:30])([F:29])[F:31])=[CH:26][CH:27]=3)=[N:12]2)=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 6328Methyl iodideHCID 18954846HCID 18954846, compound

Product 1

HCID 18954835HCID 18954835, compound

Procedure

A mixture of 0.54 g of the compound from Step C and 0.1 mL of iodomethane were stirred overnight after which time the precipitated solids were filtered and dried. This product was suspended in 2 mL of chloroform and 2 mL of 5% aqueous sodium bicarbonate was added. After stirring overnight the layers were separated and the chloroform extracts dried over magnesium sulfate and concentrated to afford 0.12 g of the title compound as a yellow oil.

Workup

  1. filtrationwere filtered
  2. customdried
  3. addition2 mL of 5% aqueous sodium bicarbonate was added
  4. stirringAfter stirring overnight the layers
  5. customwere separated
  6. dry with materialthe chloroform extracts dried over magnesium sulfate
  7. concentrationconcentrated

Sources & evidence

ORD record
ord-99f5291617844d0b8229f67b0c5cc595
Source dataset
uspto-grants-1994_11
Patent number
US05369121

Reaction notes

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