4'-Butylaminomethyl-2-cyanobiphenyl → 2-ethoxycarbonylbutanoic acid N-butyl-N-(2'-cyano-biphenyl-4-ylmethyl)-amide

HRID 2380680Notes

Reaction equation

HRID 2380680 reaction equation
[CH2:1]([NH:5][CH2:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[C:19]#[N:20])=[CH:9][CH:8]=1)[CH2:2][CH2:3][CH3:4].[Cl-].[CH2:22]([O:24][C:25](=[O:32])[CH:26]([CH2:30][CH3:31])[C:27](O)=[O:28])[CH3:23]>>[CH2:1]([N:5]([CH2:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[C:19]#[N:20])=[CH:9][CH:8]=1)[C:27](=[O:28])[CH:26]([C:25]([O:24][CH2:22][CH3:23])=[O:32])[CH2:30][CH3:31])[CH2:2][CH2:3][CH3:4]

Participants

3

Reactant 2

HCID 153383534'-Butylaminomethyl-2-cyanobiphenylHCID 86748288Ethylmalonic acid monoethyl ester monochloride

Product 1

HCID 538521992-ethoxycarbonylbutanoic acid N-butyl-N-(2'-cyano-biphenyl-4-ylmethyl)-amide

Procedure

The starting material can be prepared, for example, as follows: Analogously to Example 4b) and using 2.64 g of N-butyl-N-(2'-cyanobiphenyl-4-ylmethyl)-amine and 2.68 g of ethylmalonic acid monoethyl ester monochloride as starting materials, there is obtained 2-ethoxycarbonylbutanoic acid N-butyl-N-(2'-cyano-biphenyl-4-ylmethyl)-amide that has an Rf value of 0.65 [CH2Cl2 /CH3OH (95:5)].

Sources & evidence

ORD record
ord-ac99490fd0024110b712c18a14666f45
Source dataset
uspto-grants-1994_11
Patent number
US05369110

Reaction notes

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